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Description

In 2005 I finished my postdoctoral studies at the Faculty of Chemistry in Santiago de Compostela (Spain). I immediately went to work at a pharmaceutical company.  My first job was to make a chromatographic column to isolate a byproduct, honestly during the doctorate and postdoc I gathered a lot of experience, so this task was very easy. The second task was to synthesize a naproxen methanesulfonate salt. This was not so easy for me and although during my doctorate I took several chemistry courses among which are: total synthesis, fine chemical synthesis, free radicals, palladium chemistry, enzyme chemistry, sugar chemistry and organometallic. The reality is that I didn't know how to execute the task. When searching for pharmaceutical salts, many references appeared, but very few specifying how the formation of salts works.  I found some details such as: Reaction details Reaction conditions Susceptibility to water Susceptibility to environmental factors Isolation  Ion bond formation Counterions  Purification Methods Impact of Hydrochlorides on Industrial Stainless-Steel Equipment Toxicity  Improvement of physicochemical characteristics The data gathered was not exhaustively described and consequently it was difficult to execute this work. Fortunately, I carried out several experiments.