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Animal diseases that infect humans are a major threat to human health and global biodiversity. Among these zoonosis, the Monkeypox virus is an Orthopoxvirus found in the forest regions of Central, West and East Africa. In the DRC, mpox is endemic, with numerous cases reported in Tshuapa province since 2010. The MPXV reservoir remains unknown, as do the risk factors leading to transmission of the Monkeypox virus. Thus, in an effort to provide answers to uncertain research questions, we conducted 2 studies from 9 March to 15 April 2016 for first study and for the second study, the fieldwork was conducted over a period of four months in 2021 (March–April and July–August) in Tshuapa province, using different methods. These included radiotelemetry and qualitative method to assess human behaviors that might serve as a pathway for Monkeypox virus transmission by wild animals. Our results showed that the C. emini species appears to have a bimodal activity pattern, with nocturnal activity between 6:00 pm and 5:00 am, with a probable reduction in activity between 8:00 pm - 11:00 pm and around 4:00 am, and nocturnal activity between 6:00 am and 5:00 pm, with a probable cessation of activity between 11:00 am and 2:00 pm. The same data showed that humans and these animals share the same habitats on a daily basis, as they (C. emini) choose burrow habitats located in disturbed sites such as mixed agricultural areas. This proximity of the burrows observed during the present work to human activity means that these animals are relatively easy to capture. This is a cause for concern, as these rodents are a potential reservoir of MPXV and other zoonosis. In addition, the data gathered in the second study have enabled us to answer research questions on interactions between humans and animal species most likely to be reservoirs of MPXV, to identify local players in Tshuapa province most likely to be exposed to zoonosis (e.g. MPXV) and to identify behaviors that could present a risk of zoonotic transmission of MPX. Such identification offers the opportunity to protect them not only from infection, but also from the love they have for eating game meat during an epidemic.