Book

Frontotemporal dementia (FTD) and motor neuron disease (MND) represent complex neurodegenerative disorders with overlapping clinical, pathological, and molecular features. This book provides a comprehensive exploration of the FTD–MND spectrum, integrating clinical observations with current literature and emerging scientific perspectives. Through a detailed case presentation, this work highlights the diagnostic challenges of patients presenting with behavioral changes, cognitive impairment, parkinsonian features, and motor neuron involvement. The discussion emphasizes the importance of multidisciplinary assessment, including neurological examination, neuroimaging, electrophysiological studies, and supportive management strategies. The book also reviews current understanding of the molecular mechanisms underlying FTD–MND overlap, including TDP-43 pathology and C9orf72-associated disease, while discussing advances in biomarkers and potential future therapeutic approaches. Designed for neuropsychiatrists, neurologists, psychiatrists, neuroscientists, healthcare professionals, and students interested in neurodegenerative diseases, this book offers valuable insights into one of the most challenging and evolving areas of cognitive and motor disorders.