Book

Bioinorganic Antimicrobials: Mechanisms and Therapeutic Applications focuses on the application of bioinorganic chemistry to efficiently fight the increasing problem of antimicrobial resistance (AMR). Initially, the global threat of AMR is addressed, then the book illustrates how metal ions and bioinorganic complexes might be the next big thing in antimicrobial drugs. The subject of coordination chemistry is dealt with thoroughly, e.g., types of ligands, coordination numbers, stability factors, and the biological mode of action of metal complexes. Furthermore, this volume traces the microbial molecular-level mechanisms of the antimicrobial effects of metal ions by describing their binding to DNA, proteins, enzymes, and the microbial metabolism. The text is peppered with examples of the properties of silver, copper, iron, gold, and zinc complexes. Furthermore, the book critically evaluates the most recent developments in the field, such as hybrid metal-antibiotic complexes, metal-based nanosystems, and resistance-overcoming strategies. The authors indicate green synthesis, advanced drug delivery, and multi-targeted antimicrobial approaches as future avenues to explore. After presenting the applications, the clinical trials, and the regulatory considerations of this new generation of drugs, this volume is a must-have for research scientists, graduate students, and professionals working in chemistry, pharmacy, and biomedical sciences.