Book

Most pharmaceutical compounds are subjected to degradation process with subsequent partial or complete loss of pharmacological activity or even the conversion into harmful or toxic byproducts. Besides the usual offline methods of analysis, online monitoring of in vivo degradation of drugs to its major metabolites by electrochemical determination using Ion Selective Electrodes (ISEs) presents a groundbreaking tool to understand deeply its pharmacokinetic properties to improve more effective and less toxic medicines. This book is concerned with stability indicating determination of the intact molecules of some drugs containing carboxylic acid derivatives (Atracurium besylate & Thiocolchicoside) in presence of its degradation products (in vitro/in vivo), with different accurate, precise and selective analytical techniques (Spectrophotometric, Ion-selective electrodes based potentiometric and chromatographic methods).