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The book is a research based evidence for scientific community. Scholars can find empirical information from the book. Psoriasis is a global burden of disease characterized by the presence of well circumscribed erythematous papule & plaque of various size & shape, covered by silvery scales and has an inflammatory nature demonstrated by excessive secretion of dermal, systemic, pre-inflammatory cytokines. Furthermore, liver stimulation and the production of acute phase reactants such as C-reactive Protein (CRP), which is considered an inflammatory biomarker, are believed to stem from IL-6 secretion induced by TNF-a. CRP is an acute phase reaction protein biomarker that is identifiable within 24 to 48 hours after tissue damage or infection. Sample was selected by purposive sampling technique. Data were collected from the informant and recorded in structured case report form. Clinical examination and relevant investigation were done meticulously. Mean age of the patient was 39.42±8.5 years.  Study shows that maximum patients (37.0%) had CRP value 3.1-6.0. The average CRP value was 4.2±1.2. On correlation between severity of psoriasis with CRP value revealed that, out of 24 patients of severe disease, 13(54.1%) cases was ≥9.1 and 8(33.3%) cases was 6.1-9.0 CRP. On the other hand maximum patients [34 (44.7)] of mild cases had CRP 3.1-6.0. CRP was significantly elevated (>6 mg/L) in severe psoriatic patients with severe disease than those with mild disease. The mean CRP values in mid disease (PASI<10) was 0.9±0.2 and in severe cases (PASI>10) was 7.5±2.1. There was a significant difference in CRP values with PASI score. So, CRP shows a significant association with severity of psoriasis. From this study, we suggest that CRP value is a good predictor in the diagnosis and disease severity of psoriasis.